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The Niners go into Oakland on the back of an embarrassing 19-3 loss to the Seattle Seahawks that saw them drop to 7-5 and ended a three-game winning run.
San Francisco's playoff destiny is now not in their own hands and Jim Harbaugh's men will look hope that they can finally get things going on offense and get back to winning ways. The 49ers will also be looking for the Seahawks and Arizona Cardinals to suffer defeats against the Philadelphia Eagles and Kansas City Chiefs to put them a game back in the NFC West race.
Meanwhile, the Raiders come into this one on the back of a 52-0 shellacking at the hands of the St Louis Rams. That dreadful defeat dropped Oakland to 1-11 and the hosts, led by rookie quarterback Derek Carr, will be playing for little more than Bay Area pride at the O.Co Coliseum.
Injuries
Right tackle Anthony Davis has again been ruled out for the 49ers as he is still experiencing symptoms of the concussion he sustained in the win over the New York Giants in Week 11.
Tight end Vance McDonald (back) and nose tackle Glenn Dorsey (forearm) are again unavailable, while cornerback Tramaine Brock, wide receiver Brandon Lloyd and special teams ace Bubba Ventrone are all inactive.
Jonathan Martin will fill in for Davis and a strong game is sure to be required from the former Miami Dolphin versus a decent Oakland defense.
Brock's absence will see Chris Culliver and Perrish Cox serve as starting corners again with Dontae Johnson likely operating in the slot. Quinton Patton takes Lloyd's spot on the gameday roster, with receiver and return man Bruce Ellington making his comeback from injury.
The two major inactives for the Raiders are British-born tackle Menelik Watson and receiver Denarius Moore. Exciting running back Latavius Murray is active.
How, where and when?
The game kicks-off at 9.25pm (BST) at the Coliseum. It is not being broadcast on Sky Sports aside from on their feed of the NFL's RedZone channel. Therefore if you want to catch the Battle of The Bay then you will need a GamePass subscription or get yourself to the 49erFaithfulUK Facebook page for our gameday thread!
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